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Similarly, ED50 (i.e., the concentration at which half maximal symptom suppression is achieved) may be measured and may be, for example, increased by at least 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 200%, 300%, 400%, 500%, 600%, 700%, 800%, 900%, 1000%, or more relative to the absence of administration of the agent