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These signaling axes not only govern chondrocyte proliferation and ECM secretion but also modulate epigenetic regulators, including histone acetyltransferases (e.g., p300/CBP) and microRNAs (e.g., miR-140), which stabilize the chondrocyte phenotype by suppressing catabolic genes (e.g., MMP13) and reinforcing anabolic gene expression
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Size:10,000 mcg per 15 mL tube
GABA exerts its effects by binding to two distinct receptors, GABA-A (GABA A ) and GABA-B (GABA B ) that are members of the ion channel (ionotropic) receptors
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