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METAOD002: A Phase IIa (double-blind, placebo-controlled 4 × 4 Latin Square design) safety study with single doses (25, 50 and 100 µg/kg AOD9604) administered intravenously to 23 healthy clinically obese males presenting with a BMI ≥ 35 kg/m 2

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[9] It is important to remember that the biochemical mechanisms altering synaptic plasticity occur at the level of individual synapses of a neuron