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Quinazolines Alongside classical phthalazin-1(2H)-one cores, PARP inhibitor design increasingly explores alternative rigid heteroaromatic scaffolds, particularly 4(3H)-quinazolinones and quinoxaline frameworks, as NAD+-competitive chemotypes that can preserve the key hydrogen-bonding pattern within the nicotinamide-binding pocket of PARP-1/2 [171,172,173]
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