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IGF-1 elevation is not a surrogate endpoint for disease modification [25] Congestive Heart Failure Signal (Growth Hormone-Deficient Adults Trial) Research Focus : MK-677 in growth hormone-deficient adults (trial halted early) Key Results : 4 of 62 MK-677 subjects (6.5%) developed congestive heart failure versus 1 of 60 placebo subjects (1.7%)
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