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These results highlight the multifaceted role of NNMT in lipid metabolism, adipokine regulation, and autophagy, all of which contribute to the development of hyperlipidemia (Table 1, Figure 2)

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In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 μg vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)