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To determine the role of GpoA during pneumococcal infection, we constructed the ΔgpoA mutant in the capsulated D39 strain (serotype 2), which is virulent in BALB/c mice using intranasal inoculation [38], and its corresponding revertant strain ( wt gpoA + )
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However, their efficacy remains inconsistent, and concerns regarding long-term safety have limited their widespread use [71,72]
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