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Main regulator of iron absorption is Hepcidin Hepcidin protein is encoded by HAMP gene and secreted by liver Hepcidin name is because it is hepatocellular protein with bactericidal activities Hepcidin binds to the cellular iron efflux channel ferroportin causing its internalization and proteolysis, there by inhibiting the release of iron from intestinal cells and macrophages Thus hepcidin lowers plasma iron levels and conversely deficiency of hepcidin causes iron overload Transcription of hepcidin is increased by cytokines and iron and decreased by iron deficiency, hypoxia and ineffective erythropoiesis Reference

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In mammals, PPP occurs in the cytoplasm of cells in various organs, including the liver, mammary glands, and adrenal glands, where it plays a vital role in generating high levels of NADPH required for biosynthetic processes (Figure 2) (Warburg and Christian, 1931