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Hippocrates apparently wrote in Greek ὠφελέειν ή μὴ βλάπτειν (roughly translated into Latin as primum non nocere) in his passage from the treatise on Epidemics (First book, second part, paragraph 5)
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Later work added mitochondria-to-nucleus signaling under metabolic stress, direct activation of CK2 in skeletal muscle, and reduced atrophy signaling
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