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Overexpression of IREB2 indirectly leads to a significant decrease in lung compliance and total lung capacity, while it can cause inflammatory infiltration to increase IL-6 expression, induce hepcidin to regulate iron homeostasis, and induce FEV1 decline in COPD mice ( DNA dioxygenase 10-11 translocation 2 (TET2) is an important demethylase that regulates cigarette induced lipid peroxidation by demethylating GPX4, thereby reducing ferroptosis in COPD airway epithelial cells ( In conclusion, the role of pulmonary iron regulation as well as iron metabolism in COPD remains to be investigated.Targeted iron therapy and lipid-specific anti-oxidation may be a strategy for the treatment of COPD and needs to be more reliably validated
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