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Venetoclax with Azacitidine Disrupts Energy Metabolism and Targets Leukemia Stem Cells in Acute Myeloid Leukemia Patients - PMC

GPX4 mainly protects cell membranes from oxidative attack, and studies have pointed out that there are three different subtypes, namely sperm karyotype, mitochondrial type and cytoplasmic type, which can catalyze complex lipid hydroperoxides such as phospholipids, cholesterol, and cholesterol esters in addition to H 2 O 2 (Bersuker et al., 2019)

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Similarly, the European Medicines Agency (EMA) has published reflections on the qualification of novel methodologies, providing a conceptual framework for their evaluation (223)

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