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David Baker's Institute for Protein Design at the University of Washington, winner of the 2024 Nobel Prize in Chemistry alongside Demis Hassabis and John Jumper of Google DeepMind, has demonstrated that AI can generate novel protein and peptide structures with specified functions from first principles — binding a desired receptor, inhibiting a defined enzyme, modulating a specific signaling pathway.18 Applied to anti-inflammatory targets like NLRP3, TNF-α, and the NF-κB pathway, this capability is opening a design space of potential therapeutic peptides that dwarfs anything accessible through natural product discovery

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However, a lack of organelles, especially mitochondria, limits the cell death machinery of mature erythrocytes and their ability to undergo specific, regulated cell death modes