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Key natural products, their phytoconstituents, and pharmacological activities relevant to GI disorders are summarized in Table 2 , 37,164–194 while their integrative therapeutic mechanisms are illustrated in Figure 3

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What they found: Significant improvement in muscle insulin signaling (AKT/mTOR pathway) Increased expression of genes for mitochondrial biogenesis Increased expression of tissue remodeling Drop in HOMA-IR of ~25 % No adverse events Why it matters: This was the first high-quality randomized clinical trial of NMN in humans