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2.6 Probiotics and gut microbiota modulation The human gut microbiome has rapidly emerged as a critical and modifiable cancer susceptibility, treatment-response, and survivorship determinant, including in breast cancer where the paradigm has attracted attention to probiotics and gut-microbiota targeting as promising adjunctive strategies (174)

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Consequently, simulations suggest that while doxorubicin redox metabolism impacts GSH metabolism, the concentrations required to illicit a toxic response, with either a single or extended exposure, reside outside that of the therapeutic dosing range