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Science 282 1998 Synthesis and Biological Activity of Highly Potent Heptapeptide Analogs of Somatostatin with C-Terminal Modifications Janecka A and Zubrzycka M Endocrine Regulations 35 2001 Case Study-2 : δ-Opioid Receptor Agonists¶ Therapeutic utility of δ-Opioid Receptor Agonists¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Typical Peptide δ-Opioid Receptor Agonists¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Typical Non-Peptide δ-Opioid Receptor Agonists¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Pharmacophore for δ-Opioid Receptor Agonists¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 SAR, NMR and Modeling of the DPDPE series (1/3)¶ articles X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 SAR, NMR and Modeling of the DPDPE series (2/3)¶ articles X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 SAR, NMR and Modeling of the DPDPE series (3/3)¶ articles X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Bioactive Conformation of DPDPE (1/4)¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Bioactive Conformation of DPDPE (2/4)¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Bioactive Conformation of DPDPE (3/4)¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Bioactive Conformation of DPDPE (4/4)¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Scaffold Design of Non-Peptide Antagonists¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 Refinement of the Scaffold and Substituents¶ Amino Group not Included¶ Reducing the Number of Chiral Centers¶ Substituent with Variable Hydrophobicity¶ articles De Novo Design, Synthesis, and Biological Activities of High-Affinity and Selective Non-Peptide Agonists of the δ-Opioid Receptor Liao S, Alfaro-Lopez J, Shenderovich MD, Hosohata K, Lin J, Li X, Stropova D, Davis P, Jernigan KA, Porreca F, Yamamura HI and Hruby VJ Journal of Medicinal Chemistry 41 1998 A Three-Dimensional Model of the d-Opioid Pharmacophore: Comparative Molecular Modeling of Peptide and Nonpeptide Ligands Shenderovich MD, Liao S, Qian X and Hruby VJ Biopolymers 53 2000 X-ray Structure of [D-Pen2,D-Pen5]enkephalin, a Highly Potent, d Opioid Receptor-Selective Compound: Comparisons with Proposed Solution Conformations Flippen_Anderson JL, Hurby VJ, Collins N, George C and Cudney B Journal of the American Chemical Society 116 1994 The First Series Synthesized¶ 50 of 8.4 nM