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360−364 Notably, they have created macrocyclic peptides featuring a nonreducible, interside-chain-to-side-chain thioether linkage by achieving a cross-linking reaction between a genetically encoded alkyl bromide-bearing ncAA O -(2-bromoethyl)-tyrosine (O2beY) using an engineered Mj TyrRS/tRNA CUA pair and a proximal cysteine thiol group 360,364 (Figure 16a), and they combined this technique with a low-throughput, plate-based assay to develop a macrocyclic peptide inhibitor targeting the Sonic Hedgehog/Patched 1 interaction
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