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If you experience a flare-up 24 hours after, your symptoms would be considered “irritable” and you may need to go back to the drawing board and manipulate the ROM or dosage again

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Besides, there are some unresolved limitations in the use of HGs as scaffolds in tissue regeneration and vascularization, such as design challenges and dimensions of the gel network, the presence of inert modules that can destabilize microporous and macroporous structures, as well as the difficulty of producing rational scaffold designs that can efficiently mimic the morphology of the extracellular matrix (Xu et al., 2022)