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Sulfur as a Signaling Nutrient Through Hydrogen Sulfide - PMC

(For reviews, see Anders, 2004, Anders, 2008, Cooper, 1998, Cooper and Pinto, 2008, Cooper et al., 2011, Dekant, 2003, Dekant et al., 1994.) The reactive fragments generated from haloalkene cysteine S -conjugates by the action of cysteine S -conjugate β-lyases are especially cytotoxic in experimental animals to the proximal renal tubules, in particular to the S 3 ( pars recta ) region and, to a lesser extent, the S 1 and S 2 ( pars convoluta ) region (e.g., Jones et al., 1988) and to isolated human proximal tubules (Chen et al., 1990)

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