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In AD models, phospho-tau colocalizes with lipid rafts enriched in polyunsaturated fatty acids, and ω-6 fatty acids such as arachidonic acid have been shown to promote tau oligomerization (128, 129)

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The core of GCE lies in its ability to redefine or expand the genetic alphabet, by identifying specific positions in messenger RNA’s open reading frame through nonsense codons, quadruplet codons, and rare sense codons