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Together, these findings support oxidative stress as an upstream driver that activates NFκB while also disrupting additional pathogenic pathways, consistent with evidence that NFκB interacts with multiple molecular networks involved in immune regulation, oxidative stress, and neurodevelopment (58)
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The most abundant subnetwork is involved in energy metabolism mediated by NADH-ubiquinone oxidoreductase (NDUFS1) and NADH dehydrogenase (NDUFV2), which interact with each other
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