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As per my latest article, if you use PPIs chronically, and you're experiencing worsening of migraine symptoms, ask your neurologist if you should try supplementing with magnesium and check your B12.
nNOS co-transmission inhibits both pre- and post-synaptic components of serotonergic synapses, including SERT, its behaviorally-relevant 5HT1A receptor, and serotonin neuron activity, and SSRIs disrupt many of these effects of nNOS (Chanrion et al., 2007
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Given the angiogenesis-related theoretical concern, people with active cancer or a history of cancer are the group for whom caution makes the most sense, since promoting blood-vessel growth around existing malignant cells is the specific worry
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