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In the case of cyanine dyes with anionic groups (e.g., sulphate or carboxy), their possible interaction with metal ion should be also considered

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These data indicate that 10,000 K white LED light has a much stronger effect than 2,000 K or amber light in disrupting the circadian oscillations, which supports our notion that CIL is critical when considering the harmful effect of LEDs on the circadian clock system