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A recent systematic review and meta-analysis found no difference in B12 levels between patients with subclinical hypothyroidism and those with hyperthyroidism, whereas hypothyroid patients had lower B12 levels than healthy adults (8)

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Exosome miR-484 in skeletal muscle was found to target and downregulate ACSL4 expression, upregulate GPX4 and SLC7A11 expression in brain tissue, inhibit neuronal ferroptosis and lipid peroxidation, and promote nerve repair ( 6 Conclusion and perspective Iron, an essential trace element and pivotal signaling molecule in the nervous system, can drive ferroptosis, which contributes to the pathogenesis of NDDs such as AD, PD, MS, and ALS