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NO released from the vascular endothelium is also an antioxidative factor that neutralizes O 2 − [76] and impairment of NO synthesis marks the onset of endothelial dysfunction that is mainly mediated by the endothelial NO synthase (eNOS) uncoupling mechanism [77]
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104 The inactivation of AMPK is linked to hepatic lipid accumulation, hyperinsulinemia and hyperglycemia in animal models with HFD induced NAFLD
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