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Constipation in B12 deficiency is primarily neurogenic, due to autonomic and enteric neuropathy causing slow gut motility • Constipation may precede anemia • Often improves after B12 replacement • Think of B12
Thiol oxidation favors both the release of Ca 2+ ions from the endoplasmic reticulum and the formation of misfolded protein aggregates, which also favor mitochondrial malfunction (see Figure 1a)
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NCOR1 deficiency triggers lipid synthesis in hepatocytes by increasing FASN and acetyl-CoA carboxylase (ACC) expression
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