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Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial - The Lancet
In addition, they enable a much faster determination of the penetration properties and screening of a broader range of compounds
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Importantly, BH4 depletion and disruption of the BH4/BH2 ratio can lead to NOS-uncoupling and the formation of superoxide and peroxynitrite
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